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Is Meiosis II identical to Mitosis? The second cell division in Meiosis is known as Meiosis II. Meiosis II is very similar to Mitosis. In both cases chromosomes line up and sister chromatids are separated by the action of the spindle fibers. The daughter cells are genetically identical to one another. There are some minor differences between Mitosis and Meiosis II. Cells at the start of Mitosis II are haploid. Cells at the start of have the normal ploidy of the organism they are in. Normally we think of Mitosis as occurring in diploid cells but in many organisms it can occur in haploid cells as well.