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What is the difference between inhibitor and activator proteins? Gene transcription is controlled by multiple factors. Some proteins bind to DNA sequences and start the process of gene transcription. RNA synthesis can only occur when these activators are bound to specific DNA sequences. Inhibitors are other molecules that prevent transcription from occurring. Inhibitors bind to activator molecules and prevent them from binding to DNA. A molecular signal is necessary to remove the inhibitor molecule from the activator and allow transcription to proceed.