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What is chromatography? chromatography is a versatile technique for separating mixtures strategy: flow the mixture over a material that retains some components more than others, so different components flow over the material at different speeds a simple analogy for chromatography mixed swarm of bees and wasps swept by the wind over a flower bed... bees visit flowers; wasps stay airborne wasps leave the bed first; swarm separated on the basis of affinity for flowers in chromatography, a mobile phase sweeps the sample over a stationary phase (as the wind sweeps the swarm over the flower bed)